The EGFR Polyclonal Antibody (CAB11575) is a valuable tool for research involving the Epidermal Growth Factor Receptor (EGFR), a cell surface receptor that plays a crucial role in cell growth and proliferation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the EGFR protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in cancer biology and signal transduction pathways.The EGFR receptor is known for its involvement in multiple cellular processes, including cell differentiation, survival, and migration.
Dysregulation of EGFR signaling has been implicated in various cancers, making it a promising target for cancer therapy research. By understanding the function and regulation of EGFR, researchers can develop new strategies for targeted cancer treatments and personalized medicine approaches. The EGFR Polyclonal Antibody is a critical tool for investigating the complex role of EGFR in both normal and disease states, paving the way for advancements in cancer therapy and precision medicine.
Product Name:
EGFR Rabbit Polyclonal Antibody
SKU:
CAB11575
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 960-1060 of human EGFR (NP_005219.2).
Cell membrane, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus membrane, Nucleus membrane, Nucleus, Secreted, Single-pass type I membrane protein.
Calculated MW:
134kDa
Observed MW:
180kDa
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Purification Method:
Affinity purification
Gene ID:
1956
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using EGFR Rabbit pAb (CAB11575) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
