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EFNA4 Antibody (PACO00768)

SKU:
PACO00768
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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EFNA4 Antibody (PACO00768)

The EFNA4 Polyclonal Antibody (PACO00768) is a valuable tool for researchers studying EFNA4, a member of the ephrin family of cell surface proteins involved in cell signaling and development. This antibody, produced in rabbits, is highly specific to human EFNA4 and has been validated for use in various applications, including Western blot and immunofluorescence.EFNA4 plays a critical role in mediating cell-cell communication and is known to be involved in processes such as axon guidance, angiogenesis, and neuronal migration.

Dysregulation of EFNA4 expression has been implicated in various diseases, including cancer, neurodevelopmental disorders, and cardiovascular diseases. The EFNA4 Polyclonal Antibody enables researchers to study the expression and localization of EFNA4 in different cell types and tissues, providing valuable insights into its function and potential therapeutic applications.

Antibody Name:EFNA4 Antibody
Antibody SKU:PACO00768
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the C-terminal region of human Ephrin-A4.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:EFNA4; EPLG4; LERK4; Ephrin-A4; EPH-related receptor tyrosine kinase ligand 4; LERK-4
UniProt Protein Function:EFNA4: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. Belongs to the ephrin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ligand, receptor tyrosine kinase; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: extracellular region; integral to plasma membrane; plasma membrane

Molecular Function:ephrin receptor binding; protein binding; transmembrane-ephrin receptor activity

Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway

NCBI Summary:This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:P52798
NCBI GenInfo Identifier:3821237
NCBI Gene ID:1945
NCBI Accession:CAA06993.1
UniProt Secondary Accession:P52798,O95457, Q5SR71, Q6FI57, C9JHJ8, G3XAK2,
UniProt Related Accession:P52798
Molecular Weight:22,584 Da
NCBI Full Name:ephrin-A4
NCBI Synonym Full Names:ephrin-A4
NCBI Official Symbol:EFNA4  
NCBI Official Synonym Symbols:EFL4; EPLG4; LERK4  
NCBI Protein Information:ephrin-A4
UniProt Protein Name:Ephrin-A4
UniProt Synonym Protein Names:EPH-related receptor tyrosine kinase ligand 4; LERK-4
Protein Family:Ephrin
UniProt Gene Name:EFNA4  
UniProt Entry Name:EFNA4_HUMAN

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