E2A/TCF3 Monoclonal Antibody (CAB23946)
- SKU:
- CAB23946
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | E2A/TCF3 Monoclonal Antibody |
SKU: | CAB23946 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 379-525 of human E2A/TCF3(NP_003191.1). |
Sequence: | SPSY DGGL HGLQ SKIE DHLD EAIH VLRS HAVG TAGD MHTL LPGH GALA SGFT GPMS LGGR HAGL VGGS HPED GLAG STSL MHNH AALP SQPG TLPD LSRP PDSY SGLG RAGA TAAA SEIK REEK EDEE NTSA ADHS EEEK KELK APR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | TCF3; AGM8; E2A; E47; ITF1; TCF-3; VDIR; bHLHb21; transcription factor 3; E2A/TCF3 |
Positive Sample: | Jurkat,Mouse ovary |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 67kDa/68kDa |
Observed MW: | 75kDa/67-80kDa |
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
Purification Method: | Affinity purification |
Gene ID: | 6929 |
Clone Number: | ARC61947 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |