The DYRK1B Polyclonal Antibody (PAC021994) is a cutting-edge tool for researchers studying the role of DYRK1B in various cellular processes. DYRK1B is a dual-specificity tyrosine-phosphorylation-regulated kinase that plays a critical role in cell growth, proliferation, and differentiation.This antibody, generated in rabbits, is highly specific and sensitive to human samples, making it an ideal choice for Western blot applications. By binding to DYRK1B, researchers can accurately detect and analyze the expression levels of this important protein in different cell types.DYRK1B is known to be involved in various diseases, including cancer, neurodevelopmental disorders, and metabolic disorders.
By studying the function of DYRK1B using this antibody, researchers can gain valuable insights into disease mechanisms and potentially pave the way for the development of novel therapeutic strategies targeting DYRK1B.Overall, the DYRK1B Polyclonal Antibody (PAC021994) is a valuable tool for researchers interested in exploring the role of DYRK1B in health and disease. Its high specificity, sensitivity, and reliability make it a must-have for any laboratory conducting research in the fields of cancer biology, neurobiology, and molecular biology.
Antibody Name:
DYRK1B Antibody (PACO21994)
Antibody SKU:
PACO21994
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human DYR1B.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells, using DYR1B antibody.
Background:
Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Grimwood J., Nature 428:529-535(2004).
DYRK1B: a dual-specificity protein kinase of the DYRK family. Localizes in the nucleus, where it enhances the transcriptional activity of TCF1/HNF1A. A co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Induced by members of the Rho-family in myoblasts. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. Contains a bipartite nuclear targeting signal sequence. Three splice-variant isoforms have been described.Protein type: Kinase, protein; EC 2.7.12.1; Protein kinase, dual-specificity (non-receptor); Protein kinase, CMGC; CMGC group; DYRK family; Dyrk1 subfamilyChromosomal Location of Human Ortholog: 19q13.2Molecular Function: protein binding; protein kinase activity; transcription coactivator activityBiological Process: positive regulation of transcription, DNA-dependent; protein amino acid phosphorylationDisease: Abdominal Obesity-metabolic Syndrome 3
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
