| UniProt Protein Function: | DUSP11: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.-; Phosphatase (non-protein)Chromosomal Location of Human Ortholog: 2p13.1Cellular Component: nuclear speck; nucleusMolecular Function: phosphoric monoester hydrolase activity; polynucleotide 5'-phosphatase activity; protein tyrosine phosphatase activity; RNA bindingBiological Process: protein amino acid dephosphorylation; RNA metabolic process; RNA processing |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008] |
| UniProt Code: | O75319 |
| NCBI GenInfo Identifier: | 33991073 |
| NCBI Gene ID: | 8446 |
| NCBI Accession: | |
| UniProt Secondary Accession: | O75319,Q6AI47, Q9BWE3, B2RCT8 |
| UniProt Related Accession: | O75319 |
| Molecular Weight: | |
| NCBI Full Name: | Homo sapiens dual specificity phosphatase 11 (RNA/RNP complex 1-interacting), mRNA |
| NCBI Synonym Full Names: | dual specificity phosphatase 11 |
| NCBI Official Symbol: | DUSP11Â Â |
| NCBI Official Synonym Symbols: | PIR1Â Â |
| NCBI Protein Information: | RNA/RNP complex-1-interacting phosphatase |
| UniProt Protein Name: | RNA/RNP complex-1-interacting phosphatase |
| UniProt Synonym Protein Names: | Dual specificity protein phosphatase 11; Phosphatase that interacts with RNA/RNP complex 1 |
| Protein Family: | RNA/RNP complex-1-interacting phosphatase |
| UniProt Gene Name: | DUSP11Â Â |
| UniProt Entry Name: | DUS11_HUMAN |
