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DUSP11 Antibody (PACO17395)

SKU:
PACO17395
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • DUSP11 Antibody PACO17395
  • DUSP11 Antibody PACO17395
$407
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Description

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DUSP11 Antibody (PACO17395)

The DUSP11 Polyclonal Antibody (PAC017395) is a valuable tool for researchers studying DUSP11, a phosphatase enzyme involved in the regulation of signaling pathways and gene expression. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to the DUSP11 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it ideal for investigations in the fields of molecular biology and signal transduction.DUSP11, also known as dual-specificity phosphatase 11, is known to play a crucial role in the modulation of various cellular processes, such as cell growth, differentiation, and stress responses.

Understanding the function and regulation of DUSP11 is essential for unraveling the complexities of intracellular signaling cascades and their implications in diseases like cancer, neurodegenerative disorders, and inflammatory conditions. The DUSP11 Polyclonal Antibody is a valuable tool for researchers aiming to elucidate the roles of this enzyme in health and disease.

Antibody Name:DUSP11 Antibody (PACO17395)
Antibody SKU:PACO17395
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:Human
Immunogen:Full length fusion protein
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17395(DUSP11 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17395(DUSP11 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.
Synonyms:dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
UniProt Protein Function:DUSP11: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.-; Phosphatase (non-protein)Chromosomal Location of Human Ortholog: 2p13.1Cellular Component: nuclear speck; nucleusMolecular Function: phosphoric monoester hydrolase activity; polynucleotide 5'-phosphatase activity; protein tyrosine phosphatase activity; RNA bindingBiological Process: protein amino acid dephosphorylation; RNA metabolic process; RNA processing
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
UniProt Code:O75319
NCBI GenInfo Identifier:33991073
NCBI Gene ID:8446
NCBI Accession:
UniProt Secondary Accession:O75319,Q6AI47, Q9BWE3, B2RCT8
UniProt Related Accession:O75319
Molecular Weight:
NCBI Full Name:Homo sapiens dual specificity phosphatase 11 (RNA/RNP complex 1-interacting), mRNA
NCBI Synonym Full Names:dual specificity phosphatase 11
NCBI Official Symbol:DUSP11  
NCBI Official Synonym Symbols:PIR1  
NCBI Protein Information:RNA/RNP complex-1-interacting phosphatase
UniProt Protein Name:RNA/RNP complex-1-interacting phosphatase
UniProt Synonym Protein Names:Dual specificity protein phosphatase 11; Phosphatase that interacts with RNA/RNP complex 1
Protein Family:RNA/RNP complex-1-interacting phosphatase
UniProt Gene Name:DUSP11  
UniProt Entry Name:DUS11_HUMAN
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