The DUOXA1 Polyclonal Antibody (PACO50114) is a valuable tool for researchers studying DUOXA1, an essential component of the dual oxidase (DUOX) enzyme complex involved in reactive oxygen species (ROS) generation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in applications such as Western blot and immunohistochemistry.DUOXA1 plays a crucial role in regulating ROS production, which is important for various cellular processes, including immune response, signal transduction, and host defense against pathogens. Dysregulation of DUOXA1 has been linked to oxidative stress-related diseases, such as cancer, neurodegenerative disorders, and inflammatory conditions, making it a potential target for therapeutic intervention.
By targeting DUOXA1 with the PACO50114 antibody, researchers can investigate the mechanisms underlying ROS generation and its impact on cellular function. This antibody enables the detection and analysis of DUOXA1 expression in different cell types, providing valuable insights for studies in immunology, cancer biology, and redox signaling pathways. Understanding the role of DUOXA1 in oxidative stress-related conditions may lead to the development of novel treatments that target ROS production for therapeutic benefits.
Antibody Name:
DUOXA1 Antibody (PACO50114)
Antibody SKU:
PACO50114
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Dual oxidase maturation factor 1 protein (73-183AA)
DUOXA1: May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1 (Probable). Belongs to the DUOXA family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 15q21.1Cellular Component: membrane
UniProt Protein Details:
NCBI Summary:
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
