The DTX4 Antibody (PAC046710) is a valuable tool for research involving DTX4, a key protein involved in the ubiquitination and degradation of target proteins. This polyclonal antibody, raised in rabbits, is highly specific for human samples and is validated for use in various applications, including Western blot and immunohistochemistry.DTX4, also known as RNF155, plays a crucial role in maintaining cellular homeostasis by regulating protein turnover and cell signaling pathways. Its involvement in protein degradation makes it a promising target for studying diseases such as cancer, neurodegenerative disorders, and autoimmune conditions.
By understanding the function of DTX4, researchers can uncover new insights into disease mechanisms and potential therapeutic targets.Overall, the DTX4 Antibody is a valuable tool for researchers interested in studying the role of DTX4 in cellular processes and disease pathology. Its high specificity and versatility make it an essential component in studies related to protein degradation and cellular signaling pathways.
Antibody Name:
DTX4 Antibody (PACO46710)
Antibody SKU:
PACO46710
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human E3 ubiquitin-protein ligase DTX4 protein (167-432AA)
Immunofluorescent analysis of HepG2 cells using PACO46710 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
DTX4: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 6.3.2.-; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 11q12.1Cellular Component: cytosolMolecular Function: zinc ion binding; ligase activityBiological Process: regulation of interferon type I production; Notch signaling pathway; positive regulation of interferon type I production; protein ubiquitination; innate immune response
