The DRAM2 Polyclonal Antibody (PACO44803) is a valuable tool for researchers studying the DRAM2 protein, an important regulator of autophagy and cell death processes. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the DRAM2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for research in molecular biology and cancer biology.DRAM2, also known as damage-regulated autophagy modulator protein 2, plays a crucial role in maintaining cellular homeostasis by promoting autophagy and regulating cell death pathways.
Its involvement in these processes suggests its potential as a target for therapeutic interventions in diseases like cancer, neurodegenerative disorders, and metabolic conditions. Understanding the function of DRAM2 is essential for developing new strategies to manipulate autophagy and cell death mechanisms for therapeutic benefit.
Recombinant Human DNA damage-regulated autophagy modulator protein 2 protein (182-266AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human bladder cancer using PACO44803 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO44803 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human heart tissue using PACO44803 at dilution of 1:100.
Background:
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
Synonyms:
DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77), DRAM2, TMEM77
UniProt Protein Function:
TMEM77: Induces apoptotic cell death when coexpressed with DRAM1. Belongs to the DRAM/TMEM150 family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 1p13.3Cellular Component: apical plasma membrane; cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; lysosome; photoreceptor inner segmentBiological Process: photoreceptor cell maintenance; regulation of autophagy; visual perceptionDisease: Cone-rod Dystrophy 21
