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DOK6 Antibody (PACO26313)

SKU:
PACO26313
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
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Description

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DOK6 Antibody (PACO26313)

The DOK6 Polyclonal Antibody (PAC026313) is a valuable tool for researchers studying the protein DOK6, known for its role in cell signaling pathways and regulation of cellular functions. The antibody, generated in rabbits, shows high specificity towards human samples and is suitable for use in Western blot experiments. By targeting the DOK6 protein, this antibody enables researchers to study the function and expression of DOK6 in various cell types, providing insights into its potential involvement in diseases such as cancer and neurological disorders.DOK6, a member of the DOK (downstream of tyrosine kinase) family, is known to play a critical role in mediating signaling events in cells, impacting processes such as cell growth, differentiation, and survival.

Understanding the function of DOK6 is essential for unraveling its involvement in disease pathogenesis and for developing targeted therapies that can modulate its activity. The DOK6 Polyclonal Antibody is a valuable tool for researchers aiming to further explore the molecular mechanisms underlying DOK6 function and its potential as a therapeutic target.

Antibody Name:DOK6 Antibody (PACO26313)
Antibody SKU:PACO26313
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Docking protein 6 protein (109-331AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.
Synonyms:Docking protein 6 (Downstream of tyrosine kinase 6), DOK6, DOK5L
UniProt Protein Function:DOK6: ocking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Interacts via its PTB domain with phosphorylated Ret, promoting neurite growth. May have a role in brain development and/or maintenance. Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 18q22.2

Molecular Function:insulin receptor binding; protein binding

NCBI Summary:DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]
UniProt Code:Q6PKX4
NCBI GenInfo Identifier:84029601
NCBI Gene ID:220164
NCBI Accession:Q6PKX4.1
UniProt Secondary Accession:Q6PKX4,Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2, A6NNG3,
UniProt Related Accession:Q6PKX4
Molecular Weight:38,318 Da
NCBI Full Name:Docking protein 6
NCBI Synonym Full Names:docking protein 6
NCBI Official Symbol:DOK6  
NCBI Official Synonym Symbols:DOK5L; HsT3226  
NCBI Protein Information:docking protein 6
UniProt Protein Name:Docking protein 6
UniProt Synonym Protein Names:Downstream of tyrosine kinase 6
Protein Family:Docking protein
UniProt Gene Name:DOK6  
UniProt Entry Name:DOK6_HUMAN

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