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DOK3 Antibody (PACO08914)

SKU:
PACO08914
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$551
Frequently bought together:

Description

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DOK3 Antibody (PACO08914)

The DOK3 Polyclonal Antibody (PACO08914) is an essential tool for researchers studying DOK3, a key signaling molecule involved in immune cell activation and regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blotting and immunohistochemistry experiments.DOK3 is a critical mediator of immune cell signaling, playing a crucial role in the regulation of immune responses and inflammatory pathways. Its involvement in various cellular processes makes it a valuable target for investigating immune-related diseases such as cancer, autoimmune disorders, and inflammatory conditions.

By targeting DOK3, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.The DOK3 Polyclonal Antibody is a reliable tool for detecting and studying DOK3 expression in various cell types, providing researchers with valuable information for their immunology and cancer research studies. Its high reactivity and specificity make it a valuable asset for those looking to further understand the role of DOK3 in immune regulation and disease pathology.

Antibody Name:DOK3 Antibody (PACO08914)
Antibody SKU:PACO08914
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human DOK3
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:docking protein 3;DOK3;DOKL;FLJ22570;FLJ39939 ;
UniProt Protein Function:DOK3: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with SHIP. May modulate Abl function. Upon tyrosine phosphorylation, Dok3 interacts with CSK and SHIP via their SH2 domains. Both pY381 and pY398 are required for interaction with SHIP. Only pY381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Does not interact with RasGAP. Four isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q35.3

Molecular Function:protein binding

UniProt Code:Q7L591
NCBI GenInfo Identifier:84029599
NCBI Gene ID:79930
NCBI Accession:Q7L591.2
UniProt Secondary Accession:Q7L591,Q8N864, Q9BQB3, Q9H666, E9PAT0, H7BXS0,
UniProt Related Accession:Q7L591
Molecular Weight:24,737 Da
NCBI Full Name:Docking protein 3
NCBI Synonym Full Names:docking protein 3
NCBI Official Symbol:DOK3  
NCBI Official Synonym Symbols:DOKL  
NCBI Protein Information:docking protein 3
UniProt Protein Name:Docking protein 3
UniProt Synonym Protein Names:Downstream of tyrosine kinase 3
Protein Family:Docking protein
UniProt Gene Name:DOK3  
UniProt Entry Name:DOK3_HUMAN

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