Anti-DNAJC3 Antibody (PACO14816)

Antibody Name:	DNAJC3 Antibody (PACO14816)
Antibody SKU:	PACO14816
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human DNAJC3

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14816(DNAJC3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14816(DNAJC3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).

Background:	This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR).
Synonyms:	DnaJ (Hsp40) homolog, subfamily C, member 3

UniProt Protein Function:	Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
UniProt Protein Details:
NCBI Summary:	This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
UniProt Code:	Q13217
NCBI GenInfo Identifier:	5453980
NCBI Gene ID:	5611
NCBI Accession:	NP_006251.1
UniProt Secondary Accession:	Q13217,Q86WT9, Q8N4N2
UniProt Related Accession:	Q13217
Molecular Weight:	55
NCBI Full Name:	dnaJ homolog subfamily C member 3
NCBI Synonym Full Names:	DnaJ heat shock protein family (Hsp40) member C3
NCBI Official Symbol:	DNAJC3
NCBI Official Synonym Symbols:	P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK
NCBI Protein Information:	dnaJ homolog subfamily C member 3
UniProt Protein Name:	DnaJ homolog subfamily C member 3
UniProt Synonym Protein Names:	Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58
Protein Family:
UniProt Gene Name:	DNAJC3
UniProt Entry Name:

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)