The DNAH3 Polyclonal Antibody (PAC038346) is a valuable tool for research involving DNAH3, a component of the dynein complex responsible for microtubule sliding in cilia and flagella. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the DNAH3 protein, researchers can detect and analyze its expression in various cell types, making it ideal for studies in cell biology and ciliary function research.DNAH3 is essential for the proper function of cilia and flagella, structures involved in cell motility and signaling. Dysregulation of DNAH3 has been implicated in various genetic disorders affecting cilia, leading to conditions such as primary ciliary dyskinesia.
By studying DNAH3 expression and activity, researchers can gain insights into the mechanisms underlying these disorders and potentially develop targeted therapies to treat them.Overall, the DNAH3 Polyclonal Antibody is a valuable tool for researchers interested in exploring the role of DNAH3 in ciliary function and its implications for human health. Its high specificity and reactivity make it a reliable choice for Western blot analysis and other experimental techniques in the field of cilia biology.
Antibody Name:
DNAH3 Antibody (PACO38346)
Antibody SKU:
PACO38346
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Dynein heavy chain 3, axonemal protein (1-150AA)
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO38346 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO38346 at dilution of 1:100.
Background:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
Synonyms:
Dynein heavy chain 3, axonemal (Axonemal β dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b), DNAH3, DNAHC3B
UniProt Protein Function:
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly ().
UniProt Protein Details:
NCBI Summary:
This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]
