The DMP1 Polyclonal Antibody (CAB16832) is a valuable tool for researchers studying the Dentin Matrix Protein 1 (DMP1) protein, which plays a crucial role in bone and dentin mineralization. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications.DMP1 is a key regulator of mineralization and is essential for proper bone formation and maintenance. Dysregulation of DMP1 has been implicated in various bone disorders, making it a target of interest in the field of skeletal biology research.
By using the DMP1 Polyclonal Antibody, researchers can accurately detect and analyze DMP1 expression in a variety of cell types, providing valuable insights into its function and role in bone mineralization processes.With its high reactivity and specificity, the DMP1 Polyclonal Antibody is a reliable tool for investigating the intricate mechanisms underlying bone mineralization and potential therapeutic targets for bone-related diseases. It is a valuable asset for researchers in the fields of bone biology, dentistry, and musculoskeletal research.
Product Name:
DMP1 Rabbit Polyclonal Antibody
SKU:
CAB16832
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DMP1 (NP_004398.1).
Sequence:
MKIS ILLM FLWG LSCA LPVT RYQN NESE DSEE WKGH LAQA PTPP LESS ESSE GSKV SSEE QANE DPSD STQS EEGL GSDD HQYI YRLA GGFS RSTG KGGD
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
1758
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Mouse testis, using DMP1 antibody (CAB16832) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
