DMBT1 Antibody (PACO17791)
- SKU:
- PACO17791
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
DMBT1 Antibody (PACO17791)
The DMBT1 Polyclonal Antibody (PAC017791) is a valuable tool for researchers studying DMBT1, a protein involved in various biological processes such as innate immunity, cell adhesion, and inflammation regulation. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it a reliable choice for Western blot applications.DMBT1, also known as Deleted in Malignant Brain Tumors 1, is a multifunctional protein that plays a role in host defense against pathogens by binding to various microorganisms and promoting their clearance.
Additionally, DMBT1 has been implicated in tumor suppression, wound healing, and mucosal immune responses.The DMBT1 Polyclonal Antibody allows for the detection and analysis of DMBT1 protein expression in different cell types, making it suitable for research in immunology, cancer biology, and infectious diseases. By understanding the functions and regulation of DMBT1, researchers can gain insights into its potential therapeutic applications in conditions such as cancer, inflammatory disorders, and infectious diseases.
| Antibody Name: | DMBT1 Antibody (PACO17791) |
| Antibody SKU: | PACO17791 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human DMBT1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO17791(DMBT1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. |
| Synonyms: | deleted in malignant brain tumors 1 |
| UniProt Protein Function: | DMBT1: May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly- sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. Defects in DMBT1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well. Belongs to the DMBT1 family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Oncoprotein; Membrane protein, integral; Tumor suppressor; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q26.13 Cellular Component: cytoplasm; extracellular region; extracellular space; extrinsic to membrane; phagocytic vesicle membrane; zymogen granule membrane Molecular Function:calcium-dependent protein binding; pattern recognition receptor activity; protein binding; scavenger receptor activity Biological Process: cellular protein metabolic process; epithelial cell differentiation; induction of bacterial agglutination; innate immune response Disease: Glioma Susceptibility 1; Medulloblastoma |
| NCBI Summary: | Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q9UGM3 |
| NCBI GenInfo Identifier: | 85687556 |
| NCBI Gene ID: | 1755 |
| NCBI Accession: | Q9UGM3.2 |
| UniProt Secondary Accession: | Q9UGM3,Q59EX0, Q5JR26, A6NDG4, A6NDJ5, A8E4R5, B1ARE7 B1ARE8, B1ARE9, B1ARF0, B7Z8Y2, F8WEF7, |
| UniProt Related Accession: | Q9UGM3 |
| Molecular Weight: | 124,452 Da |
| NCBI Full Name: | Deleted in malignant brain tumors 1 protein |
| NCBI Synonym Full Names: | deleted in malignant brain tumors 1 |
| NCBI Official Symbol: | DMBT1Â Â |
| NCBI Official Synonym Symbols: | SAG; GP340; muclin  |
| NCBI Protein Information: | deleted in malignant brain tumors 1 protein |
| UniProt Protein Name: | Deleted in malignant brain tumors 1 protein |
| UniProt Synonym Protein Names: | Glycoprotein 340; Gp-340; Hensin; Salivary agglutinin; SAG; Surfactant pulmonary-associated D-binding protein |
| Protein Family: | Deleted in malignant brain tumors 1 protein |
| UniProt Gene Name: | DMBT1Â Â |
| UniProt Entry Name: | DMBT1_HUMAN |
Related Products
Human Deleted In Malignant Brain Tumors 1 (DMBT1) ELISA Kit
Mouse Deleted in malignant brain tumors 1 protein (Dmbt1) ELISA Kit (MOEB1472)
Human Deleted in malignant brain tumors 1 protein (DMBT1) ELISA Kit (HUEB1727)
Rat Deleted in malignant brain tumors 1 protein (Dmbt1) ELISA Kit (RTEB1077)
Porcine Deleted in malignant brain tumors 1 protein (DMBT1) ELISA Kit (PREB0428)
