UniProt Protein Function: | DENND2D: a guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous lesions. Two isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, RabChromosomal Location of Human Ortholog: 1p13.3Cellular Component: cytoplasmMolecular Function: protein binding; Rab guanyl-nucleotide exchange factor activityBiological Process: positive regulation of GTPase activity |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q9H6A0 |
NCBI GenInfo Identifier: | 426214085 |
NCBI Gene ID: | 79961 |
NCBI Accession: | NP_001258762.1 |
UniProt Secondary Accession: | Q9H6A0,Q5T5V6, Q9BSU0 |
UniProt Related Accession: | Q9H6A0 |
Molecular Weight: | 53,148 Da |
NCBI Full Name: | DENN domain-containing protein 2D isoform b |
NCBI Synonym Full Names: | DENN/MADD domain containing 2D |
NCBI Official Symbol: | DENND2DÂ Â |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | DENN domain-containing protein 2D |
UniProt Protein Name: | DENN domain-containing protein 2D |
UniProt Synonym Protein Names: | |
Protein Family: | DENN domain-containing protein |
UniProt Gene Name: | DENND2DÂ Â |
UniProt Entry Name: | DEN2D_HUMAN |