The DEFB126 Polyclonal Antibody (PAC026209) is a valuable tool for researchers studying DEFB126, a protein involved in the innate immune system's defense against microbial infections. This antibody, produced through rabbit immunization, exhibits high specificity for human samples and is suitable for use in Western blot assays. By binding to the DEFB126 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential resource for studies in immunology and microbiology.DEFB126, also known as defensin beta 126, acts as an antimicrobial peptide, protecting the body from harmful pathogens by disrupting their cell membranes. Its role in innate immune defense makes it a promising target for research into infectious diseases, including bacterial and fungal infections.
Understanding the functions of DEFB126 can lead to the development of novel therapeutics that enhance the body's natural defenses against microbial invaders.Overall, the DEFB126 Polyclonal Antibody (PAC026209) is a valuable tool for researchers seeking to unravel the intricate mechanisms of the innate immune system and develop innovative approaches to combat infectious diseases. Its high specificity and reliability make it a trusted resource for studies aimed at expanding our knowledge of host-pathogen interactions and potential therapeutic interventions.
Antibody Name:
DEFB126 Antibody (PACO26209)
Antibody SKU:
PACO26209
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Pongo pygmaeus
Immunogen:
Recombinant Pongo pygmaeus Beta-defensin 126 protein (21-63AA)
Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte. In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation ().
