The DEFB112 Polyclonal Antibody (PAC020399) is specifically designed for research involving DEFB112, a member of the defensin beta superfamily known for its antimicrobial properties. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various immunoassays, including Western blotting. By binding to the DEFB112 protein, this antibody enables accurate detection and analysis in a range of cell types, making it a valuable tool for studies in microbiology and infectious disease research.
DEFB112 is a key player in the innate immune response, acting as a natural antibiotic by disrupting microbial cell membranes. Its role in host defense against pathogens makes it a promising target for investigation in infectious diseases, antimicrobial resistance, and immune system dysregulation. Through understanding the function of DEFB112, researchers can potentially uncover new strategies for combating microbial infections and developing novel antimicrobial therapies.
Antibody Name:
DEFB112 Antibody (PACO20399)
Antibody SKU:
PACO20399
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human DEFB112
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20399(DEFB112 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds.
Background:
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alph&int∫-defensins, bet&int∫-defensins and thet&int∫-defensins. All bet∫-defensin genes are densely clustered in four to five syntenic chromosomal regions.
Synonyms:
defensin, β 112
UniProt Protein Function:
DEFB112: Has antibacterial activity. Belongs to the beta-defensin family.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 6p12.3Cellular Component: cell surfaceBiological Process: defense response to bacterium; innate immune response
UniProt Protein Details:
NCBI Summary:
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]
