The DCBLD2 Monoclonal Antibody (PACO16144) is a valuable tool for researchers studying DCBLD2, a transmembrane protein involved in cell signaling and regulation. Developed from mouse hybridomas, this antibody demonstrates high specificity and sensitivity towards DCBLD2 in human samples, making it suitable for various experimental techniques, including Western blotting and immunofluorescence.DCBLD2, also known as ESDN, is known for its role in angiogenesis and cell adhesion, making it a promising target for cancer research and vascular biology studies. Its expression pattern and function in different cell types suggest its involvement in various physiological processes, highlighting its potential as a therapeutic target in diseases such as cancer and cardiovascular disorders.
This DCBLD2 antibody is a reliable tool for investigating the role of DCBLD2 in different cellular contexts, providing valuable insights into its function and potential implications in disease pathology. By utilizing this antibody, researchers can further advance their understanding of DCBLD2 and its significance in cellular processes and disease mechanisms.
Antibody Name:
DCBLD2 Antibody (PACO16144)
Antibody SKU:
PACO16144
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human DCBLD2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16144(DCBLD2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16144(DCBLD2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
CLCP1 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1), also known as DCBLD2 (discoidin, CUB and LCCL domain containing 2) or ESDN, is a 775 amino acid, single-pass type I membrane protein that contains one CUB domain, one LCCL domain and one F5/8 type C domain. Expressed at high levels in heart, testis and skeletal muscle, CLCP1 is thought to regulate vascular smooth muscle cell (VSMC) proliferation and remodeling and may be involved in the transformation and metastasis of various cancers, such as metastatic lung cancer and gastric carcinoma.
Synonyms:
discoidin, CUB and LCCL domain containing 2
UniProt Protein Function:
DCBLD2: a type-I transmembrane protein. May be involved in vascular remodeling and influence vascular smooth muscle cell proliferation. Contains a CUB domain and a coagulation factor V/VIII homology domain, similar to the structure of the neuropilins. Plays a role in cell motility. SEMA4B appears to be one of its ligands. Strongly expressed in nerve bundles. Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells. Increased in lung cancers during the process of tumor progression. A target of EGF signaling in the A431 cervical cancer cell-line. Two isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 3q12.1|3Cellular Component: cell surface; integral to plasma membraneMolecular Function: protein bindingBiological Process: negative regulation of cell growth; wound healing
