CUX1 Antibody (PACO21776)
- SKU:
- PACO21776
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CUX1 Antibody (PACO21776)
The CUX1 Antibody (PAC021776) is a cutting-edge research tool designed for the study of the CUX1 protein, a key transcription factor involved in cell cycle regulation and development. This polyclonal antibody, specifically developed for use in research applications, is produced in rabbits and exhibits high reactivity with human samples.With validation for use in Western blot applications, the CUX1 Antibody binds specifically to the CUX1 protein, enabling precise detection and analysis in a variety of cell types. This makes it an excellent tool for researchers in the fields of molecular biology, cell biology, and cancer research who are interested in understanding the role of CUX1 in cellular processes.
CUX1, also known as cut-like homeobox 1, is known to play a critical role in regulating gene expression and cell proliferation. Dysregulation of CUX1 has been linked to various diseases, including cancer, making it a promising target for therapeutic interventions. By studying the activity of CUX1 using this antibody, researchers can gain valuable insights into its function and potential implications for disease pathogenesis and treatment strategies.
| Antibody Name: | CUX1 Antibody (PACO21776) |
| Antibody SKU: | PACO21776 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from N-terminal of human CUTL1. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Rong Zeng W., Gene 241:75-85(2000). |
| Clonality: | Polyclonal |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from K562 cells, using CUTL1 antibody. |
| Synonyms: | CCAAT displacement protein; CDP; Cut-like 1; |
| UniProt Protein Function: | CUTL1: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Membrane protein, integral; Transcription factor Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: integral to Golgi membrane; nucleus; cytosol Molecular Function:sequence-specific DNA binding; chromatin binding Biological Process: regulation of transcription from RNA polymerase II promoter; intra-Golgi vesicle-mediated transport; transcription, DNA-dependent; multicellular organismal development; auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; kidney development; lung development |
| NCBI Summary: | The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011] |
| UniProt Code: | P39880 |
| NCBI GenInfo Identifier: | 296439379 |
| NCBI Gene ID: | 1523 |
| NCBI Accession: | P39880.3 |
| UniProt Secondary Accession: | P39880,Q6NYH4, Q75LE5, Q75MT2, Q75MT3, Q86UJ7, Q9UEV5 B3KV79, J3KQV9, |
| UniProt Related Accession: | P39880,Q13948 |
| Molecular Weight: | 77 kDa |
| NCBI Full Name: | Homeobox protein cut-like 1 |
| NCBI Synonym Full Names: | cut-like homeobox 1 |
| NCBI Official Symbol: | CUX1Â Â |
| NCBI Official Synonym Symbols: | CDP; CUX; p75; CASP; CDP1; COY1; Clox; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317Â Â |
| NCBI Protein Information: | protein CASP; cut homolog; homeobox protein cux-1; CCAAT displacement protein; golgi integral membrane protein 6; putative protein product of Nbla10317 |
| UniProt Protein Name: | Homeobox protein cut-like 1 |
| UniProt Synonym Protein Names: | CCAAT displacement protein; CDP; Homeobox protein cux-1 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | CUX1Â Â |
| UniProt Entry Name: | CUX1_HUMAN |
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