C-Reactive Protein (CRP) Rabbit Polyclonal Antibody (CAB15659)
The CRP Polyclonal Antibody (CAB15659) is a valuable tool for researchers studying C-reactive protein (CRP), an important biomarker for inflammation and cardiovascular disease. The antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in a variety of applications, including Western blotting. By targeting the CRP protein, this antibody enables the detection and analysis of CRP levels in different research settings, making it an essential component for studies in immunology, cardiovascular health, and inflammatory conditions.CRP, an acute-phase reactant produced by the liver in response to inflammation, is a key indicator of systemic inflammation and is associated with various diseases, including cardiovascular disorders, infections, and autoimmune conditions.
Monitoring CRP levels can help researchers understand the underlying mechanisms of these diseases and develop targeted therapies to improve patient outcomes. The CRP Polyclonal Antibody provides a reliable tool for investigating the role of CRP in disease pathogenesis and evaluating its potential as a biomarker for diagnostic and therapeutic purposes.
Product Name:
C-Reactive Protein (CRP) Rabbit Polyclonal Antibody
SKU:
CAB15659
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-50 of human C-Reactive Protein (CRP) (NP_000558.2).
The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection.
Purification Method:
Affinity purification
Gene ID:
1401
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse plasma, using C-Reactive Protein (CRP) Rabbit pAb (CAB15659) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
