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CRABP1 Monoclonal Antibody [PAT1A1AT] (CPAB0545)

SKU:
CPAB0545
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT1A1AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

CRABP1 Monoclonal Antibody [PAT1A1AT] (CPAB0545)

The CRABP1 Polyclonal Antibody (CPAB0545) is a valuable tool for researchers studying CRABP1, a protein involved in the transport and metabolism of retinoic acid. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding to the CRABP1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in developmental biology and cancer research.CRABP1, also known as cellular retinoic acid-binding protein 1, plays a crucial role in the regulation of cellular retinoic acid levels, which are vital for various biological processes including cell differentiation and proliferation.

Its involvement in retinoic acid signaling pathways makes CRABP1 a promising target for research on developmental disorders, cancer, and other disease states impacted by retinoic acid dysregulation. Deepening our understanding of CRABP1 function is essential for the development of therapeutic interventions that leverage retinoic acid pathways for medical benefit.

Product Name:CRABP1 Antibody
Product Sku:CPAB0545
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CRABP1 mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CRABP1 amino acids 1-137 purified from Ecoli.
Clone:PAT1A1AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:CRABP1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:CRABP1 is a member of special carrier proteins for members of the vitamin A family. It is believed that CRABP1 has an essential role in retinoic acid-mediated differentiation and proliferation processes. Though, CRABP1 is structurally similar to the cellular retinol-binding proteins, it binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. CRABP1 is constitutively expressed and is thought to have different functions in the cell than the related CRABP2. CRABP1 forms a beta-barrel structure which accommodates hydrophobic ligands in its interior. Loss of CRABP1 function as a result of hypermethylation of its promoter leads to pathogenesis of papillary thyroid carcinoma. Furthermore, frequent methylation-associated silencing of CRABP1 is linked to esophageal squamous-cell carcinoma.
Synonyms:Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, CRABP-I, CRABP1, RBP5, CRABP, CRABPI.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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