The CPZ Polyclonal Antibody (PACO05567) is a valuable tool for researchers studying CPZ, a key enzyme involved in lipid metabolism and myelin maintenance. This rabbit-derived antibody is highly specific and reacts strongly with human samples, making it ideal for use in Western blot applications. By binding to the CPZ protein, researchers can easily detect and analyze its expression in various cell types, providing valuable insights into its role in physiological processes and disease pathogenesis.CPZ, also known as ceruloplasmin, is crucial for the proper functioning of the nervous system and has been implicated in neurodegenerative disorders such as multiple sclerosis and Parkinson's disease.
By studying CPZ expression and activity, researchers can better understand its involvement in these diseases and potentially identify new therapeutic targets for their treatment. The CPZ Polyclonal Antibody is a reliable tool for unraveling the complexities of CPZ biology and its impact on human health.
Antibody Name:
CPZ Antibody (PACO05567)
Antibody SKU:
PACO05567
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:40000, WB:1:500-1:2000
Species Reactivity:
Human, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human CPZ.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CPZ; Carboxypeptidase Z; CPZ
UniProt Protein Function:
CPZ: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; EC 3.4.17.-; Secreted, signal peptide; Protease; Extracellular matrixChromosomal Location of Human Ortholog: 4p16.1Cellular Component: proteinaceous extracellular matrixMolecular Function: zinc ion binding; metallocarboxypeptidase activityBiological Process: Wnt receptor signaling pathway; proteolysis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
