The COMMD6 Polyclonal Antibody is a valuable tool for researchers studying the COMMD6 protein, a key player in immune regulation and cellular processes. This antibody is produced in rabbits and is highly reactive with human samples, making it a reliable tool for Western blot applications. By binding to the COMMD6 protein, this antibody enables the detection and analysis of COMMD6 in various cell types, providing valuable insights for studies in immunology and cancer research.COMMD6 is known for its role in regulating immune responses and cellular pathways, making it a promising target for research in a variety of diseases, including cancer, autoimmune disorders, and inflammatory conditions.
Understanding the function of COMMD6 is essential for the development of therapies that target or modulate immune activity in these disease contexts.Overall, the COMMD6 Polyclonal Antibody is a versatile tool for researchers looking to investigate the role of COMMD6 in immune regulation and disease pathology. Its high reactivity and specificity make it an ideal choice for Western blot applications, providing reliable results for a range of experimental settings.
Antibody Name:
COMMD6 Antibody (PACO37382)
Antibody SKU:
PACO37382
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human COMM domain-containing protein 6 protein (1-85AA)
Immunohistochemistry of paraffin-embedded human brain tissue using PACO37382 at dilution of 1:100.
Background:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.
Synonyms:
COMM domain-containing protein 6, COMMD6
UniProt Protein Function:
COMMD6: Down-regulates activation of NF-kappa-B. Inhibits TNF- induced NFKB1 activation. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 13q22Cellular Component: cytoplasm; nucleusMolecular Function: NF-kappaB binding; protein bindingBiological Process: transcription, DNA-dependent; inhibition of NF-kappaB transcription factor
UniProt Protein Details:
NCBI Summary:
COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]
