CHM Rabbit Polyclonal Antibody (CAB8345)
- SKU:
- CAB8345
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | CHM Rabbit Polyclonal Antibody |
SKU: | CAB8345 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-210 of human CHM (NP_000381.1). |
Sequence: | KNHA LVTS ANST EAAD SAFL PTED ESLS TMSC EMLT EQTP SSDP ENAL EVNG AEVT GEKE NHCD DKTC VPST SAED MSEN VPIA EDTT EQP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | TCD; GGTA; REP-1; DXS540; HSD-32; CHM |
Positive Sample: | U-251MG,LO2,NCI-H460,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cytosol. |
Calculated MW: | 73kDa |
Observed MW: | 101kDa |
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 1121 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |