The CHD2 Polyclonal Antibody (CAB13478) is a valuable tool for researchers studying the CHD2 protein, a key player in chromatin remodeling and gene regulation. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CHD2 protein, researchers can accurately detect and analyze CHD2 levels in various cell types, making it ideal for studies in genetics, epigenetics, and developmental biology.
CHD2 is essential for proper chromatin organization and gene expression, with mutations in CHD2 being associated with neurodevelopmental disorders such as epilepsy and autism. Understanding the function of CHD2 is crucial for unraveling the mechanisms underlying these disorders and potentially developing targeted therapies. The CHD2 Polyclonal Antibody provides researchers with a reliable tool to further investigate the role of CHD2 in normal development and disease states.
Product Name:
CHD2 Rabbit Polyclonal Antibody
SKU:
CAB13478
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1729-1828 of human CHD2 (NP_001262.3).
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1106
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CHD2 antibody (CAB13478) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
