The CFAP45 Polyclonal Antibody (PAC020080) is a crucial tool for researchers studying CFAP45, a protein involved in cilia and flagella formation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By targeting the CFAP45 protein, this antibody allows for accurate detection and analysis in different cell types, making it essential for studies in cell biology and genetic diseases related to cilia and flagella dysfunction.CFAP45 is a key player in the assembly and function of cilia and flagella, organelles critical for cellular motility, signal transduction, and development.
Dysregulation of CFAP45 has been linked to various genetic disorders and diseases affecting cilia-driven processes. Understanding the role of CFAP45 is essential in uncovering the mechanisms underlying these conditions and developing potential therapeutic interventions. Researchers can rely on the CFAP45 Polyclonal Antibody to further explore the functions and implications of CFAP45 in health and disease.
Antibody Name:
CFAP45 Antibody (PACO20080)
Antibody SKU:
PACO20080
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human CFAP45
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20080(CFAP45 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
CCDC19 is a 466 amino acid, protein encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome, spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1 and, considering the great number of genes, there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes Lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, ParkinsonÂ’s, Gaucher disease and Usher syndrome are also associated with chromosome 1.
