The CEP72 Antibody (PAC045063) is a key tool for research in the field of cell biology and cancer. This polyclonal antibody is raised in rabbits and specifically targets the CEP72 protein, which plays a crucial role in centrosome duplication and cell division processes. With its high reactivity towards human samples, this antibody is validated for use in Western blot applications, enabling accurate detection and analysis of CEP72 expression in various cell types.CEP72 is known for its involvement in centrosome maturation and spindle assembly, making it a pivotal player in ensuring proper cell division and genomic stability. Dysregulation of CEP72 has been linked to chromosome instability and tumorigenesis, highlighting its potential as a therapeutic target in cancer research.
By studying the function and regulation of CEP72, researchers can gain valuable insights into the mechanisms underlying cell cycle progression and tumorigenesis.Overall, the CEP72 Antibody (PAC045063) is a valuable tool for researchers looking to explore the molecular mechanisms governing cell division and potential therapeutic strategies for cancer treatment. Its specificity and reliability make it an essential asset for studies aiming to unravel the complex interplay between centrosome dynamics and oncogenesis.
Recombinant Human Centrosomal protein of 72 kDa protein (200-460AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot. All lanes: CEP72 antibody at 3.37µg/ml + Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 72, 22 kDa. Observed band size: 72 kDa..
Immunohistochemistry of paraffin-embedded human testis tissue using PACO45063 at dilution of 1:100.
Background:
Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2.
Synonyms:
Centrosomal protein of 72 kDa (Cep72), CEP72, KIAA1519
UniProt Protein Function:
CEP72: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Belongs to the CEP72 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Microtubule-bindingChromosomal Location of Human Ortholog: 5p15.33Cellular Component: centrosome; cytosolMolecular Function: protein bindingBiological Process: centriole replication; G2/M transition of mitotic cell cycle; gamma-tubulin complex localization; spindle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. [provided by RefSeq, Jul 2008]
