The CEP19 Polyclonal Antibody (PAC052682) is a valuable tool for researchers studying CEP19, a centrosomal protein associated with ciliogenesis and the cell cycle. This antibody, produced in rabbits, exhibits strong reactivity with human samples and is well-suited for use in a variety of applications, including immunofluorescence and immunohistochemistry.CEP19 plays a crucial role in the organization and function of the centrosome, a key cellular organelle involved in cell division and ciliary assembly. By targeting CEP19, researchers can gain insights into its function and localization within the cell, aiding in the study of cell cycle regulation and ciliary dynamics.
The CEP19 Polyclonal Antibody is an essential tool for investigating the role of CEP19 in cellular processes and its potential implications in diseases linked to ciliopathies and cell cycle dysregulation. Its high specificity and sensitivity make it an excellent choice for researchers in the fields of cell biology and developmental biology.
Antibody Name:
CEP19 Antibody (PACO52682)
Antibody SKU:
PACO52682
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Centrosomal protein of 19 kDa protein (1-163AA)
Immunohistochemistry of paraffin-embedded human brain tissue using PACO52682 at dilution of 1:100.
Background:
centriole, centrosome, ciliary basal body, spindle pole
Synonyms:
Centrosomal protein of 19 kDa (Cep19), CEP19, C3orf34
UniProt Protein Function:
CEP19: Belongs to the CEP19 family.Chromosomal Location of Human Ortholog: 3q29Cellular Component: centriole; spindle poleDisease: Morbid Obesity And Spermatogenic Failure
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene localizes to centrosomes and primary cilia and co-localizes with a marker for the mother centriole. This gene resides in a region of human chromosome 3 that is linked to morbid obesity. A homozygous knockout of the orthologous gene in mouse resulted in mice with morbid obesity, hyperphagy, glucose intolerance, and insulin resistance. Mutations in this gene cause morbid obesity and spermatogenic failure (MOSPGF). This gene has a pseudogene on human chromosome 2. [provided by RefSeq, Apr 2014]
