The Anti-CELF1 Antibody (CAB1150) is a valuable tool for researchers studying CELF1, a RNA-binding protein involved in the regulation of mRNA splicing and translation. This polyclonal antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the CELF1 protein, allowing for precise detection and analysis in various cell types.CELF1 is known to play a crucial role in post-transcriptional gene regulation, particularly in the context of cell differentiation and development.
Dysregulation of CELF1 has been implicated in various diseases, including muscular dystrophy and certain types of cancer. By studying the function and expression of CELF1, researchers can gain valuable insights into the underlying molecular mechanisms of these conditions and potentially identify new therapeutic targets.
Product Name:
CELF1 Rabbit Monoclonal Antibody
SKU:
CAB1150
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CELF1 (Q92879).
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10658
Clone Number:
ARC1866
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using CELF1 Rabbit mAb (CAB1150) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
