The Cadherin-4 Polyclonal Antibody (CAB10557) is an essential tool for research involving Cadherin-4, a cell adhesion molecule with key roles in cell-cell adhesion and tissue organization. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it an ideal choice for various experimental applications.Cadherin-4, also known as R-cadherin, contributes to the maintenance of tissue integrity and cell adhesion, making it a crucial player in developmental processes and tissue morphogenesis. Its involvement in cell signaling pathways and tumor progression also positions it as a promising target for cancer research and therapeutic interventions.
By utilizing the Cadherin-4 Polyclonal Antibody, researchers can effectively detect and analyze Cadherin-4 expression in different cell types and tissues, enabling deeper insights into its functions and regulatory mechanisms. This antibody is particularly valuable for studies focused on cell adhesion, cell migration, and epithelial-mesenchymal transition, offering a versatile tool for advancing research in cell biology and cancer biology.
Product Name:
CDH4 Rabbit Polyclonal Antibody
SKU:
CAB10557
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 757-916 of human CDH4 (NP_001785.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
100kDa
Observed MW:
100kDa/115kDa
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1002
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CDH4 Rabbit pAb (CAB10557) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
