Anti-CD70 Antibody (CAB16698)
- SKU:
- CAB16698
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-CD70 Antibody (CAB16698)
The CD70 Polyclonal Antibody (CAB16698) is a valuable tool for researchers studying CD70, a member of the tumor necrosis factor (TNF) superfamily that plays a crucial role in immune response regulation. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the CD70 protein, this antibody allows for accurate detection and analysis in various cell types, making it a versatile tool for studies in immunology and cancer research.
CD70 is a key player in the immune system, known for its involvement in T cell activation, proliferation, and differentiation. Its role in regulating immune responses makes it a promising target for research in autoimmune diseases, cancer, and other inflammatory conditions. Understanding the function of CD70 is essential for developing targeted therapies that manipulate the immune system to treat these diseases effectively.
| Antibody Name: | Anti-CD70 Antibody |
| Antibody SKU: | CAB16698 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CD70. |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human CD70. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 970 |
| Uniprot: | P32970 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 21kDa/23kDa |
| Observed MW: | Refer to figures |
| Synonyms: | CD70, CD27-L, CD27L, CD27LG, TNFSF7, TNLG8A |
| Background: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. |
| UniProt Protein Function: | CD70: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Belongs to the tumor necrosis factor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cytokine Chromosomal Location of Human Ortholog: 19p13 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane Molecular Function:protein binding; protease binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: cell proliferation; cell-cell signaling; immune response; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32970 |
| NCBI GenInfo Identifier: | 21431837 |
| NCBI Gene ID: | 970 |
| NCBI Accession: | P32970.2 |
| UniProt Secondary Accession: | P32970,Q53XX4, Q96J57, B4DPR8, |
| UniProt Related Accession: | P32970 |
| Molecular Weight: | 193 |
| NCBI Full Name: | CD70 antigen |
| NCBI Synonym Full Names: | CD70 molecule |
| NCBI Official Symbol: | CD70Â Â |
| NCBI Official Synonym Symbols: | CD27L; CD27LG; TNFSF7Â Â |
| NCBI Protein Information: | CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7 |
| UniProt Protein Name: | CD70 antigen |
| UniProt Synonym Protein Names: | CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD_antigen: CD70 |
| Protein Family: | CD70 antigen |
| UniProt Gene Name: | CD70Â Â |
| UniProt Entry Name: | CD70_HUMAN |
 | Immunofluorescence analysis of rat spleen using CD70 Polyclonal Antibody (CAB16698) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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