The CD106 Polyclonal Antibody is specially developed for researchers studying CD106, also known as VCAM-1, a cell adhesion molecule involved in immune responses and inflammation. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it ideal for Western blot applications. By binding specifically to the CD106 protein, researchers can accurately detect and analyze its expression in various cell types, providing valuable insights into immunology and cancer research.
CD106 plays a vital role in immune regulation by mediating leukocyte adhesion to vascular endothelium during inflammatory processes. Its involvement in inflammation and immune cell recruitment makes it a key player in diseases such as atherosclerosis, inflammatory bowel disease, and rheumatoid arthritis. Research into the function of CD106 is essential for developing targeted therapies to modulate immune responses in these diseases, ultimately leading to improved treatment options for patients.
Product Name:
CD106 Polyclonal Antibody
SKU:
CAB23263
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant protein of mouse CD106.
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
CD106; Vcam-1
Positive Sample:
RAW264.7(Negative control),Mouse spleen
Conjugate:
Unconjugated
Calculated MW:
81kDa
Observed MW:
85-100kDa
Predicted to enable integrin binding activity and primary amine oxidase activity. Acts upstream of or within several processes, including cellular response to glucose stimulus; chorio-allantoic fusion; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in apical plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; extraembryonic component; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human VCAM1 (vascular cell adhesion molecule 1).
Purification Method:
Affinity purification
Gene ID:
22329
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CD106 Rabbit pAb (CAB23263) at 1:2500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
