The CBY1 Polyclonal Antibody (PACO45238) is specifically designed for research involving CBY1, a protein involved in cellular signaling pathways and regulation. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various research applications, including Western blot and immunofluorescence. It binds specifically to the CBY1 protein, allowing for accurate detection and analysis in a variety of cell types.CBY1 is known to play a role in multiple cellular processes, including cell proliferation, migration, and differentiation. Its function in signaling cascades makes it a key target for studies in cell biology and cancer research.
By understanding the activity of CBY1, researchers can gain insights into its role in disease development and potentially identify new therapeutic targets for treating cancers and other diseases.Overall, the CBY1 Polyclonal Antibody (PACO45238) is a valuable tool for researchers interested in exploring the functions of CBY1 and its implications in various cellular processes and diseases. Its high reactivity and specificity make it a reliable choice for experiments aimed at deciphering the role of CBY1 in biological pathways and disease mechanisms.
Recombinant Human Protein chibby homolog 1 protein (1-126AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot. All lanes: CBY1 antibody IgG at 5.3µg/ml + Mouse lung tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 14 kDa. Observed band size: 14 kDa..
Immunohistochemistry of paraffin-embedded human heart tissue using PACO45238 at dilution of 1:100.
Background:
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
CBY1: Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 22q12Cellular Component: cytosol; nucleoplasm; nucleus; trans-Golgi networkMolecular Function: beta-catenin binding; identical protein binding; protein bindingBiological Process: cardiac muscle cell differentiation; fat cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt receptor signaling pathway; protein localization
UniProt Protein Details:
NCBI Summary:
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
