Cathepsin L/V/K/H Rabbit Monoclonal Antibody (CAB4986)
- SKU:
- CAB4986
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CATL
- CTSL1
- MEP
- Research Area:
- Cell Biology
Description
Product Name: | Cathepsin L/V/K/H Rabbit Monoclonal Antibody |
SKU: | CAB4986 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Cathepsin L/V/K/H (P07711). |
Sequence: | AVWE KNMK MIEL HNQE YREG KHSF TMAM NAFG DMTS EEFR QVMN GFQN RKPR KGKV FQEP LFYE APRS VDWR EKGY VTPV KNQG QCGS CWAF SATG ALEG Q |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | MEP; CATL; CTSL1; Cathepsin L/V/K/H |
Positive Sample: | Mouse liver, Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome, Apical cell membrane, Cytoplasmic vesicle, secretory vesicle, chromaffin granule, Secreted, extracellular space, Secreted |
Calculated MW: | 38kDa |
Observed MW: | 38kDa |
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.
Purification Method: | Affinity purification |
Gene ID: | 1514/1515/1513/1512 |
Clone Number: | ARC1276 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |