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Caspase-1 p20 Monoclonal Antibody

SKU:
CAB23429
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

Product Name:Caspase-1 p20 Monoclonal Antibody
Product Code:CAB23429
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC60705
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:1000-1:5000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:THP-1, THP-1+TPA+LPS
Cellular Location:Cytoplasm, Cell membrane
Customer Validation:WB(Mus musculus)

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Caspase-1 p20(NP_001244047.1).
Sequence:DVKKN LTASD MTTEL EAFAH RPEHK TSDST FLVFM SHGIR EGICG KKHSE QVPDI LQLNA IFNML NTKNC PSLKD KPKVI IIQAC RGDSP GVVWF KDSVG
Synonyms:ICE, P45, IL1BC
Calculated MW:10KDa/29KDa/35KDa/42KDa/45KDa
Observed MW:20-25kDa

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