CAMLG Rabbit Polyclonal Antibody (CAB13720)
- SKU:
- CAB13720
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | CAMLG Rabbit Polyclonal Antibody |
SKU: | CAB13720 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human CAMLG (NP_001736.1). |
Sequence: | MESM AVAT DGGE RPGV PAGS GLSA SQRR AELR RRKL LMNS EQRI NRIM GFHR PGSG AEEE SQTK SKQQ DSDK LNSL SVPS VSKR VVLG DSVS TGTT DQQG GVAE VKGT QLGD KLDS FIKP PECS SDVN LELR QRNR GDLT ADSV QRGS RHGL EQYL SRFE EAMK LRKQ LISE KPSQ EDGN TTEE FDSF RI |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:200 |
Synonyms: | CAML; GET2; CDG2Z; CAMLG |
Positive Sample: | U-87MG,HepG2,HT-29,Mouse thymus,Mouse testis,Rat brain,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Multi-pass membrane protein. |
Calculated MW: | 33kDa |
Observed MW: | 38kDa |
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
Purification Method: | Affinity purification |
Gene ID: | 819 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |