CALM2 Rabbit Polyclonal Antibody (CAB8008)
- SKU:
- CAB8008
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | CALM2 Rabbit Polyclonal Antibody |
SKU: | CAB8008 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human CALM2 (NP_001734.1). |
Sequence: | MADQ LTEE QIAE FKEA FSLF DKDG DGTI TTKE LGTV MRSL GQNP TEAE LQDM INEV DADG NGTI DFPE FLTM MARK MKDT DSEE EIRE AFRV FDKD GNGY ISAA ELRH VMTN LGEK LTDE EVDE MIRE ADID GDGQ VNYE EFVQ MMTA K |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | caM; CALM; CAM1; CAM3; CAMC; PHKD; CAMII; LQT15; PHKD2; CALML2; CAMIII; CALM2 |
Positive Sample: | NIH/3T3,MCF7,BT-474,NCI-H460,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cytoskeleton, spindle, spindle pole. |
Calculated MW: | 17kDa |
Observed MW: | 17kDa |
This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 805 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |