The C5 Polyclonal Antibody (PAC025384) is a valuable tool for researchers studying C5, a key component of the complement system involved in immune responses and inflammation. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. By targeting the C5 protein, this antibody allows for the detection and analysis of C5 in various cell types, making it ideal for studies in immunology and inflammation research.C5, a vital component of the complement system, plays a crucial role in immune defense by promoting inflammation and activating immune cells.
Dysregulation of C5 activity has been implicated in various diseases, including autoimmune disorders, infectious diseases, and inflammatory conditions. Understanding the function of C5 is essential for developing targeted therapies to modulate immune responses and combat immune-related diseases.Overall, the C5 Polyclonal Antibody (PAC025384) is a valuable tool for researchers interested in studying the role of C5 in immune responses and inflammation. Its high specificity and reliability make it an essential reagent for experiments aiming to elucidate the mechanisms underlying immune system function and dysfunction.
Antibody Name:
C5 Antibody (PACO25384)
Antibody SKU:
PACO25384
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:10-1:100
Species Reactivity:
Pig
Immunogen:
Recombinant Pig Complement C5a anaphylatoxin protein (1-74AA)
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO25384 at dilution of 1:10.
Background:
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
Synonyms:
Complement C5a anaphylatoxin, C5
UniProt Protein Function:
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
