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C2CD3 Antibody (PACO47926)

SKU:
PACO47926
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • C2CD3 Antibody PACO47926
  • C2CD3 Antibody PACO47926
  • C2CD3 Antibody PACO47926
€359

Description

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C2CD3 Antibody (PACO47926)

The C2CD3 Polyclonal Antibody (PAC047926) is a valuable tool for researchers studying C2CD3, a protein involved in ciliogenesis and centriole biogenesis. This antibody, produced in rabbits, has high specificity and sensitivity for detecting C2CD3 in human samples, making it ideal for use in Western blot applications. By targeting the C2CD3 protein, researchers can investigate its function in various cell types, providing insights into cellular processes related to cilia formation and centriole assembly.

C2CD3 is a key player in the regulation of ciliary structure and function, essential for processes such as cell signaling, motility, and sensory perception. Dysregulation of cilia formation has been linked to a range of human diseases, including ciliopathies and certain types of cancer. By studying the role of C2CD3 in these processes, researchers can gain a better understanding of disease mechanisms and potentially identify new therapeutic targets for intervention.

Antibody Name:C2CD3 Antibody (PACO47926)
Antibody SKU:PACO47926
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human C2 domain-containing protein 3 protein (2079-2265AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human testis tissue using PACO47926 at dilution of 1:100.
Product ImageImmunofluorescent analysis of Hela cells using PACO47926 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human thyroid tissue using PACO47926 at dilution of 1:100.
Background:Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3.
Synonyms:C2 domain-containing protein 3, C2CD3
UniProt Protein Function:C2CD3: 5 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 11q13.4Cellular Component: centriole; centrosome; cytosolMolecular Function: protein bindingBiological Process: neural tube development; sensory cilium biogenesis; in utero embryonic development; neural plate pattern formation; organelle organization and biogenesis; regulation of proteolysis; protein processing; brain development; heart looping; embryonic digit morphogenesis; regulation of smoothened signaling pathwayDisease: Orofaciodigital Syndrome Xiv
UniProt Protein Details:
NCBI Summary:This gene encodes a protein that functions as a regulator of centriole elongation. Studies of the orthologous mouse protein show that it promotes centriolar distal appendage assembly and is also required for the recruitment of other ciliogenic proteins, including intraflagellar transport proteins. Mutations in this gene cause orofaciodigital syndrome XIV (OFD14), a ciliopathy resulting in malformations of the oral cavity, face and digits. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
UniProt Code:Q4AC94
NCBI GenInfo Identifier:148596944
NCBI Gene ID:26005
NCBI Accession:NP_056346.3
UniProt Secondary Accession:Q4AC94,Q2NLE1, Q3C1U9, Q6ZU92, Q8IYM4, Q8NB87, Q8NDH7 Q9Y4M2, C9JR55, E2QRD1
UniProt Related Accession:Q4AC94
Molecular Weight:213,274 Da
NCBI Full Name:C2 domain-containing protein 3 isoform 2
NCBI Synonym Full Names:C2 calcium-dependent domain containing 3
NCBI Official Symbol:C2CD3  
NCBI Official Synonym Symbols:OFD14  
NCBI Protein Information:C2 domain-containing protein 3
UniProt Protein Name:C2 domain-containing protein 3
UniProt Synonym Protein Names:
Protein Family:C2 domain-containing protein
UniProt Gene Name:C2CD3  
UniProt Entry Name:C2CD3_HUMAN
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