The BRMS1 Polyclonal Antibody (CAB14865) is a valuable tool for researchers studying BRMS1, a gene associated with metastasis suppression in various cancers. This antibody, produced in rabbits, has high specificity and sensitivity for detecting BRMS1 protein expression in human samples, and is validated for use in Western blotting applications.BRMS1, also known as breast cancer metastasis suppressor 1, has been identified as a key player in inhibiting the spread of cancer cells to distant organs.
Research on BRMS1 has shown its potential as a therapeutic target for preventing metastasis and improving patient outcomes in cancer treatment.By utilizing the BRMS1 Polyclonal Antibody, researchers can investigate the mechanisms behind BRMS1-mediated metastasis suppression and explore its role in cancer progression. This antibody is a valuable tool for studies in oncology and may lead to the development of novel treatment strategies for metastatic cancers.
Product Name:
BRMS1 Rabbit Polyclonal Antibody
SKU:
CAB14865
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 90-210 of human BRMS1 (NP_056214.1).
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
25855
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BRMS1 Rabbit pAb (CAB14865) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
