The BEX1 Polyclonal Antibody (PAC040454) is a valuable tool for researchers studying BEX1, a protein associated with neurogenesis and neuronal differentiation. This antibody, derived from rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By binding to the BEX1 protein, this antibody enables researchers to detect and analyze BEX1 expression in various cell types, providing insights into its role in neurodevelopment and potential implications for neurological disorders.BEX1, also known as Brain-expressed X-linked protein 1, is a key player in regulating neuronal differentiation and survival, making it a promising target for research on neurodevelopmental disorders and brain tumorigenesis.
Understanding the function of BEX1 can provide valuable information for developing novel therapeutic strategies to treat conditions such as autism, epilepsy, and brain cancer. By using the BEX1 Polyclonal Antibody, researchers can delve deeper into the mechanisms underlying BEX1-mediated processes and potentially uncover new therapeutic targets for neurological conditions.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO40454 at dilution of 1:100.
Background:
Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states.
Synonyms:
Protein BEX1 (Brain-expressed X-linked protein 1), BEX1
UniProt Protein Function:
BEX1: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. Belongs to the BEX family.Protein type: Cell development/differentiation; Cell cycle regulationChromosomal Location of Human Ortholog: Xq22.1|Xq22Cellular Component: transcription factor complexMolecular Function: protein bindingBiological Process: positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter
