The AWAT1 Antibody (PAC0-7132) is an essential tool for investigating the AWAT1 protein, which is involved in the biosynthesis of wax esters and triglycerides. This polyclonal antibody is produced in rabbits and has been validated for its specificity in detecting AWAT1 in human samples, making it ideal for use in Western blot applications.AWAT1 plays a crucial role in lipid metabolism, specifically in the synthesis of neutral lipids that are essential for various cellular processes. Dysregulation of AWAT1 has been implicated in metabolic disorders such as obesity, diabetes, and cardiovascular disease, making it a promising target for therapeutic interventions.
With its high reactivity and specificity, the AWAT1 Antibody (PAC0-7132) offers researchers a reliable tool for studying the role of AWAT1 in lipid metabolism and its potential implications in metabolic diseases. By enabling the detection and analysis of AWAT1 in various cell types, this antibody is a valuable asset in advancing our understanding of lipid biology and developing targeted therapies for metabolic disorders.
Antibody Name:
AWAT1 Antibody (PACO07132)
Antibody SKU:
PACO07132
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the C-terminal region of human DGAT2L3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of 293T NIH-3T3 COLO cells using DGAT2L3 Polyclonal Antibody.
Western blot analysis of mouse-kidney KB lysis using DGAT2L3 antibody.
Western Blot analysis of 293 cells using DGAT2L3 Polyclonal Antibody.
DGAT2L3: Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20). Belongs to the diacylglycerol acyltransferase family.Protein type: EC 2.3.1.75; Membrane protein, integral; Membrane protein, multi-pass; TransferaseChromosomal Location of Human Ortholog: Xq13.1Cellular Component: endoplasmic reticulum membraneMolecular Function: long-chain-alcohol O-fatty-acyltransferase activityBiological Process: arachidonic acid metabolic process; wax biosynthetic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]
