AUH Rabbit Polyclonal Antibody (CAB7424)
- SKU:
- CAB7424
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | AUH Rabbit Polyclonal Antibody |
SKU: | CAB7424 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 68-339 of human AUH (NP_001689.1). |
Sequence: | SSEM KTED ELRV RHLE EENR GIVV LGIN RAYG KNSL SKNL IKML SKAV DALK SDKK VRTI IIRS EVPG IFCA GADL KERA KMSS SEVG PFVS KIRA VIND IANL PVPT IAAI DGLA LGGG LELA LACD IRVA ASSA KMGL VETK LAII PGGG GTQR LPRA IGMS LAKE LIFS ARVL DGKE AKAV GLIS HVLE QNQE GDAA YRKA LDLA REFL PQGP VAMR VAKL AINQ GMEV DLVT GLAI EEAC YAQT IPTK DRLE GLLA FKEK RPPR YKGE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | AUH |
Positive Sample: | Hep G2,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion. |
Calculated MW: | 36kDa |
Observed MW: | 33kDa |
This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 549 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |