The AP2M1 Rabbit Monoclonal Antibody is a vital tool for researchers studying the AP2M1 protein, a key component of the clathrin-coated vesicles involved in intracellular protein trafficking. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it an excellent choice for Western blot applications.AP2M1 plays a crucial role in the process of endocytosis, where it facilitates the internalization of membrane proteins and their sorting to various cellular compartments. Dysregulation of AP2M1 expression or function has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic intervention.
By utilizing the AP2M1 Rabbit Monoclonal Antibody, researchers can effectively detect and analyze AP2M1 protein levels in different cell types, allowing for a better understanding of its role in physiological and pathological processes. This antibody is a valuable tool for studies in cell biology, neuroscience, and cancer research, providing insights that can potentially lead to the development of novel therapeutic strategies.
Product Name:
AP2M1 Rabbit Monoclonal Antibody
SKU:
CAB11070
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human AP2M1 (Q96CW1).
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1173
Clone Number:
ARC0522
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AP2M1 Rabbit mAb (CAB11070) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
