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Anti-VEGFA Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0234)

SKU:
HDAB0234
Product Type:
Rabbit Monoclonal Antibody
Antibody Type:
Monoclonal Antibody
Size:
100 μg
Reactivity:
Human
Host Species:
Rabbit
Antibody Isotype:
Rabbit/Human Fc chimeric IgG1
Clone:
DMC276
Synonyms:
MVCD1, VEGF, VPF
€675
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Description

system_update_altDatasheet
SKU:HDAB0234
Size:100 µg
Clonality:Monoclonal
Clone:DMC276
Synonyms:MVCD1, VEGF, VPF
Applications:Flow Cyt
Recommended Dilution:Flow Cyt 1:100
Host Species:Rabbit
Isotype:Rabbit/Human Fc chimeric IgG1
Reactivity:Human
Purification Method:Purified from cell culture supernatant by affinity chromatography
Formulation:Powder
Buffer:1XPBS
Storage:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:Research use only
Background:This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.

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