The Anti-UAP56/DDX39B Antibody (CAB9749) is a high-quality antibody designed for research involving the UAP56/DDX39B protein, an essential component of the mRNA splicing machinery. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it an ideal tool for studying the functions and mechanisms of UAP56/DDX39B in various cellular processes.The UAP56/DDX39B protein is known to play a crucial role in pre-mRNA splicing, RNA processing, and mRNA export from the nucleus to the cytoplasm. It is also implicated in the regulation of gene expression and RNA metabolism, making it a key player in fundamental biological processes.
The Anti-UAP56/DDX39B Antibody enables the detection and analysis of UAP56/DDX39B protein levels and localization in different cell types, facilitating research in molecular biology, genetics, and oncology.By gaining a better understanding of the functions and interactions of UAP56/DDX39B, researchers can uncover its involvement in diseases such as cancer, neurological disorders, and developmental abnormalities. This antibody serves as a valuable tool for researchers aiming to dissect the roles of UAP56/DDX39B in various cellular pathways and to explore its potential as a therapeutic target in disease intervention.
Product Name:
UAP56/DDX39B Rabbit Monoclonal Antibody
SKU:
CAB9749
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 310-428 of human UAP56/DDX39B (Q13838).
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene.
Purification Method:
Affinity purification
Gene ID:
7919
Clone Number:
ARC1731
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using UAP56/DDX39B Rabbit mAb (CAB9749) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
