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[KO Validated] TGFB1 Rabbit Polyclonal Antibody (CAB18692)

SKU:
CAB18692
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
transforming growth factor beta-1
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] TGFB1 Rabbit Polyclonal Antibody
SKU:CAB18692
Size:20uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-280 of human TGF beta 1 (NP_000651.3).
Sequence:LSTC KTID MELV KRKR IEAI RGQI LSKL RLAS PPSQ GEVP PGPL PEAV LALY NSTR DRVA GESA EPEP EPEA DYYA KEVT RVLM VETH NEIY DKFK QSTH SIYM FFNT SELR EAVP EPVL LSRA ELRL LRLK LKVE QHVE LYQK YSNN SWRY LSNR LLAP SDSP EWLS FDVT GVVR QWLS RGGE IEGF RLSA HCSC DSRD NTLQ VDIN GFTT GRRG DLAT IHGM NRPF LLLM ATPL ERAQ HLQS SRHR RAL
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1; TGF beta 1
Positive Sample:293T,Mouse lung,Rat lung
Cellular Localization:Secreted, extracellular matrix, extracellular space.
Calculated MW:44kDa
Observed MW:40kDa

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

Purification Method:Affinity purification
Gene ID:7040
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using TGF beta 1 antibody (CAB18692) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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