The PRKCSH Polyclonal Antibody (CAB0894) is a valuable tool for researchers studying the PRKCSH protein, which plays a critical role in protein folding and quality control in the endoplasmic reticulum. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the PRKCSH protein, this antibody enables the detection and analysis of PRKCSH in various cell types, making it an essential reagent for studies in protein folding, ER stress, and quality control mechanisms.The PRKCSH protein, also known as protein kinase C substrate 80K-H, is involved in the biogenesis of glycoproteins, regulating their folding and trafficking within the cell.
Dysregulation of PRKCSH function has been implicated in various diseases, including liver disorders and certain types of cancer. Therefore, understanding the role of PRKCSH in protein quality control is crucial for developing targeted therapies and treatments for these diseases.Overall, the PRKCSH Polyclonal Antibody (CAB0894) is a powerful tool for researchers investigating protein folding and quality control mechanisms in the context of disease pathology, offering new insights into potential therapeutic targets and diagnostic markers.
Product Name:
GLU2B Rabbit Monoclonal Antibody
SKU:
CAB0894
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 429-528 of human PRKCSH (P14314).
This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5589
Clone Number:
ARC2549
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PRKCSH antibody (CAB0894) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
