The Anti-PCSK9 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0212) is a powerful tool for researchers studying PCSK9, a protein involved in cholesterol metabolism and cardiovascular health. This antibody, developed using cutting-edge technology, specifically targets PCSK9 in human samples and is validated for use in various applications such as immunohistochemistry and flow cytometry.PCSK9, a key player in the regulation of cholesterol levels, has gained significant attention in the medical field due to its potential as a therapeutic target for cardiovascular diseases. By binding to PCSK9, this antibody enables precise detection and analysis of the protein, providing valuable insights for studies focusing on lipid metabolism, atherosclerosis, and cardiovascular risk factors.
The Anti-PCSK9 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0212) is a reliable tool for researchers seeking to unravel the mechanisms underlying PCSK9's functions and exploring novel strategies for managing cardiovascular health. Its high specificity and sensitivity make it an essential component in research endeavors aimed at advancing our understanding of PCSK9 biology and developing innovative therapies for cardiovascular diseases.
SKU:
HDAB0212
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC222
Synonyms:
FH3, FHCL3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
