P4HB Rabbit Monoclonal Antibody (CAB19239)
- SKU:
- CAB19239
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- P4HB
- CLCRP1
- DSI
- ERBA2L
- GIT
- P4Hbeta
- PDI
- PDIA1
- PHDB
- PO4DB
- PO4HB
- PROHB
- protein disulfide-isomerase
- Research Area:
- Cell Biology
Description
Product Name: | P4HB Rabbit Monoclonal Antibody |
SKU: | CAB19239 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 409-508 of human P4HB (P07237). |
Sequence: | KLGE TYKD HENI VIAK MDST ANEV EAVK VHSF PTLK FFPA SADR TVID YNGE RTLD GFKK FLES GGQD GAGD DDDL EDLE EAEE PDME EDDD QKAV KDEL |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; CLCRP1; ERBA2L; P4Hbeta; P4HB |
Positive Sample: | Hep G2,NIH/3T3,Mouse liver,Mouse testis,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endoplasmic reticulum, Endoplasmic reticulum lumen, Melanosome, Peripheral membrane protein. |
Calculated MW: | 57kDa |
Observed MW: | 57kDa |
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
Purification Method: | Affinity purification |
Gene ID: | 5034 |
Clone Number: | ARC2398 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |